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Non-Invasive Blood glucose Tech

发表于 2016-6-21 03:53:17 | 显示全部楼层 |阅读模式
本帖最后由 John 于 2016-6-21 19:55 编辑

In April, 2015, Grove Instruments, Inc. of Worcester,Massachusetts, suddenly went bankrupt for reasons that remain unclear to this day. Grove was developing a non-invasive bloodglucose monitor based on a near-infrared through-the-earlobe optical techniquecalled the optical bridge. Almost 20 people lost their jobs, but that is notthe worst: for decades, diabetes-sufferers have been pricking their fingers toget a blood sample for blood glucose measurement, and now the leading hope, andany hope, to get rid of those fingerpricks is suddenly in grave danger.

The technology has passed scientific scrutiny ten times, asit has gained ten SBIR (Small Business Innovative Research) grants from theNIH. Extensive clinical testing has been done over many years on over 300 diabeticpersons, and the results were the best ever just before the bankruptcy. Here, I can only tell about things that have been made public in the patents. There are many facets to the technology, here is one: - Measuring blood glucose directly by absorption is impossible, and increasing the resolution of the Analog/Digital converter does not help. However, if the rate of change of the signal is used as the signal instead of the signal itself, the resulting superresolution makes it possible to measure blood glucose when the blood content of the tissue is modulated.

I, Hannu Harjunmaa, PhD, was one of the two founders ofGrove Instruments and its Chief Scientist. The company was founded in 1990under the name VivaScan Corporation, to commercialize my inventions. I am thelead inventor on most Grove patents (see list). I am pre-diabetic.

I founded Valoa Technologies, Inc. in June, 2015, tocommercialize my new inventions not involving blood glucose measurement. However, ifValoa is able to acquire the patents from the Grove estate, it will continuethe development of the non-invasive blood glucose monitor. If someone elseacquires the patents, there is no guarantee that the work will continue.

Grove Instruments was not the only company developing anon-invasive blood glucose monitor. We are aware of companies in Israel and theUK and elsewhere having active development projects using differenttechnologies. But, during the last 25 years that I have been in this business, numerouscompetitors have appeared and disappeared. Yet, someone will make it someday.

The Trustee of the bankruptcy estate has ordered an auctionto be held on January 27, 2016. The assets to be sold are, most importantly,the IP, or the USand international patents. It is impossible to predict the amount of the winningbid. That is the reason this campaign is a Flexible Funding campaign. ValoaTechnologies will go to the auction with whatever funds are raised in thiscampaign, plus a buffer whose size, for obvious reasons, cannot be disclosedhere.

The goal of this campaign is to raise enough money to winthe auction. Commercialization of a blood glucose monitor is NOT the immediate goal,although, if the campaign is a huge success, it might become possible, too.Only by acquiring the patents can we keep alive the dream of a non-invasiveblood glucose monitor. There are many players in the field of blood glucosetesting who will be severely hurt by the introduction of a non-invasive device.The companies that make test strips make billions of dollars each year on them(Global Data estimates the strip market size to be $10.9B in 2017). It isconceivable that a large company could participate in the auction, directly orindirectly, only to acquire and then shelve the patents.
If we are hugely successful, the product development maycontinue immediately. It is more probable, though, that not enough funds areraised to both win the auction and continue development. If that happens,additional funding will be sought.
The world has at least 360 million diagnosed diabetics (and many moreundiagnosed). If one percent of them donate to this project an average of $10,the money raised is $36M. That is enough to bring the non-invasive bloodglucose monitor to market.

Valoa Technologies has under development a device useful forpersons with diabetes. It is a hand-held device that can be used to measure thesugar content of beverages, such as wines, in unopened glass bottles. If Valoa does not win theauction, the funds raised in this campaign will be used to commercialize thisproduct, the Valoa Brix:
Click here to learn more about Valoa Brix

Challenge #1 is the auction itself. There is no way topredict how high a bid is needed to win it. It could be small, like $10k, ifnobody else is interested. If a big company is interested, it may drive the bidto millions of dollars. All we can say now is that more funds is better.
Beyond the auction, challenge #2 is the development of thedevice itself. Although its results are very promising, there is no guaranteethat it will get FDA approval. Another risk is that someone else gets to themarket first with a clearly superior product.

      Hannu Harjunmaa   
          Holden, United States   

 楼主| 发表于 2016-6-21 06:13:26 | 显示全部楼层

Tattoo-like sensor can detect glucose levels without a painful finger prick

ACS News Service Weekly PressPac: Wed Jan 14 16:24:07 EST 2015
                      "Tattoo-Based Noninvasive Glucose Monitoring: A Proof-of-Concept Study"
Analytical Chemistry
Scientists have developed the first ultra-thin, flexible device that sticks to skin like a rub-on tattoo and can detect a person’s glucose levels. The sensor, reported in a proof-of-concept study in the ACS journal Analytical Chemistry, has the potential to eliminate finger-pricking for many people with diabetes.
Joseph Wang and colleagues in San Diego note that diabetes affects hundreds of millions of people worldwide. Many of these patients are instructed to monitor closely their blood glucose levels to manage the disease. But the standard way of checking glucose requires a prick to the finger to draw blood for testing. The pain associated with this technique can discourage people from keeping tabs on their glucose regularly. A glucose sensing wristband had been introduced to patients, but it caused skin irritation and was discontinued. Wang’s team wanted to find a better approach.
The researchers made a wearable, non-irritating platform that can detect glucose in the fluid just under the skin based on integrating glucose extraction and electrochemical biosensing. Preliminary testing on seven healthy volunteers showed it was able to accurately determine glucose levels. The researchers conclude that the device could potentially be used for diabetes management and for other conditions such as kidney disease.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       An ultra-thin sensor could help people with diabetes monitor their blood sugar levels without drawing blood.
                                                                                                                        Credit: Jacobs School of Engineering/UC San Diego                                    
                                                                                                    High-resolution image

 楼主| 发表于 2016-6-21 06:18:56 | 显示全部楼层

Diabetes Data, Strapped to Your Wrist!

Like the rest of the D-community, we've been dreaming for a long time about a hands-free way to observe what's happening with our blood sugars -- either non-invasively, without having to even prick our skin, or at least with some kind of "smart watch" viewer that allows us to see our BG levels with just a flick of the wrist.

But from the untimely death of the early GlucoWatch and Glucoband to the unclear possibilities of Apple's rumored iWatch to the futuristic Glucose Glass concept that could display our data literally in front of our eyes, it's all been a dream somewhere down the yellow brick road, up to now.
As we ease on down that road, we've found a couple of engineering whizzes right here in our own D-Community who have actually developed working wrist watches that track blood sugars or chart data from devices already being used (your fingerstick meter or continuous glucose monitors or insulin pumps)!

One is a D-Dad with a young son diagnosed in 2012, and the other's a longtime type 1 diagnosed more than three decades ago. What they share is engineering prowess to develop smart watches with capabilities far beyond what is commercially available now. Their work signals that it is quite possible to "hack diabetes devices" to accomplish better data integration, even with garage-created makeshift gadgets.
This is home-grown diabetes device design at its best, and since that's right up our alley here at the 'Mine, we jumped right in to explore the stories behind these inventions.

John Costik: "We Could Do a Lot More..."
With backgrounds in software and mechanical engineering, husband and wife John and Laura Costik in New York found themselves flooded with information after their son, Evan, was diagnosed in August 2012 at the age of 4. They had some quick hospital D-training and went home with Evan starting on insulin shots, not using an insulin pump or CGM right away.

Almost immediately after diagnosis, John says the couple knew "we could do a lot more with the tools available. They simply needed integrating. Between the two of us, we saw tremendous opportunity to improve Evan's health and his quality of life, as well as for ourselves and our daughter."
John set up a Google site that allowed the daycare staff to log fingerstick meter checks, carb intake and insulin bolus data, and he set it up so that one or both of the parents would get emails and text messages when that data was entered. Followup was pretty quick and easy, he says, and in most cases the daycare staff could react as needed based on the care plan the couple had in place for Evan.
Then in February 2013, Evan started on the Dexcom G4 and in April, he began insulin pumping.
"It would be great if I could see his blood sugars all the time," John remembers thinking.
Using the Dexcom Studio software that the CGM company offers for free download online, John and Laura figured out how they could pull data from the G4 receiver hooking it up to a laptop and putting the computer in Evan's daycare room so he could be monitored during the day. The diabetes data would then be uploaded to the existing Google website, and John created an iOS app that both parents could use to keep track of their son's health -- pulling blood sugar readings, test times and trends so that they could quickly intervene with a phone call or message to the daycare staff.
Prepping for kindergarten this fall, John says he wanted to basically "create a mobile solution that could be carried around" or a custom ambulatory monitoring system, as it might officially be called -- something he was surprised didn't already exist! They built a case that holds both the Dexcom G4 receiver and the smartphone connected by an open source USB, and that sends the data to the cloud so it can be accessed from anywhere.

And then, John integrated the whole system into a Pebble smartwatch that he bought earlier this year, allowing him quick access to his son's D-data with just a glance at his wrist! When any new data is sent via the iOS app to the cloud, it sends a message to the custom Pebble watch app and then the watch will respond accordingly, with customized patterns of alerts or vibrations.
"It will really get my attention when Evan goes low or goes double arrows down," the dad says. "The alerts on the watch app mirror those setup in the iOS app. In addition to simple alerts based on BG value, it can alert based on trend and value. For example, if Evan's CGM shows 120 and double arrows down, it will alert me. If he was flat at 120, it wouldn't trigger the alert. Also, if we get the dreaded '???' it will also alert me. Such an alert does not exist on the G4 receiver, and it has already come in handy. I am a huge fan of having a simple, glance-able look at Evan's BG. Yes, the phone app provides the same, but with the watch, it is always available within a split second. As an overprotective father, I love it."
John says he thinks more is possible in the future, where pump data and meal nutrition data could be integrated into a single database and be communicated just as easily. That could allow for even more D-data analysis, like figuring out the effects of what their son is eating, and how a particular meal's fat content might react to a particular bolus.

"What it comes down to is: I love my family. If  I can keep T1D from taking any more from him, from all of us, I will," John says. "With this system, we can give him a non-diabetic A1C without hypoglycemia. With this system, we can sleep at night, and Evan can spend his days being the rowdy, active, happy little boy he's always been. If the work we've done can help others, I'd love to see that happen, too."
John says that Dexcom and Medtronic (pump brand Evan uses) have both been very supportive of the family's work, and he's interested in talking more about how this could be further developed and used to help the broader diabetes device world.
Of course, the Costiks aren't the only ones out there pursuing this kind of diabetes device integration into a smart watch concept...

Don Browne: Hacking a "DexWatch"
Type 1 PWD Don Browne in Massachusetts was diagnosed 33 years ago at age 12, so he's seen the evolution of diabetes tech through the years -- from the introduction of home glucose meters and insulin pumps to CGMs, and now all the software programs and smartphone apps enabling data logging and analysis.
Don's also been fooling around with electronics since he was a kid and even had a ham radio license back in the day. He says he dropped all that when he got a driver's license, and then after college worked in biotech for a few years before realizing that he could better use the skills picked up in his teen years in the field of computer programming -- where he's now been for the past 20 years.
Although he hasn't used an insulin pump, Don says he stumbled upon the Dexcom CGM a few years ago when he was Googling for improvements in monitoring tech. He switched docs to get a CGM, and that led him to pursuing something he'd long been wanting: a blood sugar watch.

"I've wanted my glucose readings on a watch for years," he says, pointing out that he tried the GlucoWatch and considers it "a complete fraud" for what it claimed to be.
"I thought about creating something using a heart rate monitor watch or a Garmin Forerunner in the past.  Then I saw a write-up on the TI Chronos (reference design for smart watch apps), and realized that this was the ideal technology."
A few years ago, he "hacked" a computerized cycle trainer to program rides into Google Street View and he used that same model to communicate with his Dexcom. Like the Costiks, Don says he used program coding to open up the Dexcom Studio to send BG data to a file and then to the watch, so that he'd be able to wear that watch while riding his motorbike in off-road Enduro events. The TI Chronos platform was the breakthrough he was looking for.
In explaining it to me, there was a lot of tech talk -- sniffing out data packets, serial traffic between the Dexcom and program, and communicating various codes. Don says he had originally tried a few different ways a couple years ago using the Dexcom 7+, but couldn't make sense of the data coming from the serial port and so he didn't aggressively pursue it. But several months ago, he upgraded to the Dexcom G4 and so he used his old 7+ as a "victim" to experiment on.
After a couple months of burning the midnight oil, Don got what he was after. First, he used a Texas Instruments watch, the eZ340-Chronos, to connect to the CGM but has since switched to a MetaWatch -- as that's the only waterproof one he's found. His G4 connects to a Raspberry PI Linux computer and communicates via Bluetooth with the smartwatch.

With his DexWatch, Don is able to see single and double up or down arrows right on his wrist, and the watch also vibrates once he's below 80 mg/dL or above 180.
"It works great, and displays what's on the (G4) device," he says. "The watch shows the minute of the last Dexcom reading, so I can tell if things have stopped.
Unlike the Costik's smartwatch that shows trends and graphs, Don says his doesn't because he was only interested in having real-time readings and immediate alerts. But he says he could easily put that trend info into a second window on the watch, allowing the user to see the full graph just by pushing a button.
Right now, the only issue he has is the battery life -- it's good for only a couple of days, unlike the first Chronos watch that had a six month or more life.
Don's been writing about his tech-creation over on an appropriately named blog, Dex Watch, and his entries go into detail about the engineering aspects of making this wearable device that displays diabetes data.

A Wristband Sleep Solution
Note that a wristwatch-style device called the Diabetes Sentry actually started shipping in the U.S. just last week... 10 years after the FDA had initially approved it! You may remember this as the Sleep Sentry before the two prior companies developing it dropped interest and went dormant, eventually leading the Minnesota-based Diabetes Sentry Products, Inc. to where it is now -- claiming to offer "the only non-invasive device currently on the world market for the detection of hypoglycemia symptoms." It's meant to be worn overnight, "when the life-threatening effects of hypoglycemia can easily go unnoticed."

It basically detects perspiration and/or a drop in skin temperature, and sounds a loud alarm to wake you up to do a fingerstick test. Not a bad idea, but the cost is $495 and it's not clear if there's any insurance coverage. Plus sweating overnight for other reasons could set it off... Still, it could provide important protection for some diabetics, both kids and adults.

D-Hackers, Unite
On the whole, it's exciting to see these clever innovations emerging from all corners -- making us less dependent on the huge Pharma Establishment for tools that make life with diabetes easier. After all, who understands our needs better than PWDs themselves?
We know there are probably many more diabetes device and data hackers out there than we've heard about. If so, please introduce yourselves!

Healthline Media

 楼主| 发表于 2016-6-21 06:32:28 | 显示全部楼层

GlucoWise-a new non-invasive glucose monitor

                        The product                A complete solution...
                        Pain-free Sensor                        This non-invasive, wireless device will take an accurate blood glucose reading every few seconds – as often as the user requires. It is positioned to gently squeeze the skin between the thumb and forefinger or the earlobe to measure blood glucose levels. The device then displays the reading in real-time on the screen.
                        Mobile App                        An easy to use, all-in-one support tool to help you track your day-to-day glucose levels. The information collected by the monitor can be uploaded wirelessly to the mobile app, allowing you to track your readings over time and merge it with other information impacting your blood glucose levels.
                        Data collected will ultimately integrate with other databases and mobile health apps and platforms, with the appropriate permissions.
                        Smart Cloud                        Our cloud-based data management system will allow you to store historical Glucowise™ data and consolidate it with other data sources.
                        If you do not have the Glucowise™ mobile app, your information can still be uploaded directly to our smart cloud through any computer USB port.

                        The Facts       
                                                                                Pain                                Over 90% of people with diabetes would welcome continuous blood glucose monitoring whilst driving and during sports or other physical activity.
                                                                        Cost                                 Over 90% of people with diabetes use a blood glucose monitor with test strips, typically costing over £800 per year.
                                                                                Convenience                                56% of people with diabetes would test themselves between 8-10 times per day if testing was painless and convenient. This is compared to just 18.3% who are already testing themselves that many times.

 楼主| 发表于 2016-6-21 09:02:16 | 显示全部楼层

Zephyr Shoe Pod -

Need some help monitoring your glucose levels? Thanks to a new invention, it could be as easy as sleeping a pair of insoles into your shoes.

New Zealand-based Zephyrinvented the inserts that detect diabetic peripheral neuropathy and track foot temperature.

“The shoe insole includes a small radio transmitter that will transmit the data to a PC via radio frequency,” according to SciFi.com. “This allows yourself, or your doc to keep an active eye on your condition and provide plenty of preventative measures to keep those feet nice, healthy and still attached.”

For those not familiar with the disease, diabetics often loss their sense of feeling in their feet, which if left untreated leads to ulcers which can sometimes require amputation.

By: Bianca Bartz - Nov 27, 2007  
                                                                                 References: blog.scifi

 楼主| 发表于 2016-6-21 09:29:28 | 显示全部楼层

Sleep Well Blood Glucose Monitoring Device Eliminates Sleepless Night

                            Sleep Well Wireless Blood Glucose Monitoring Device Eliminates Sleepless Night of Parents with Diabetic Child
                         Sleep Well is a wireless blood glucose monitoring device concept, designed aiming to eliminate the sleepless nights of parents with the tension of getting their kids glucose level down to the extreme level. The system comprises a portable and lightweight monitor with an ability to take wireless signal that parents keep with them and a wearable bracelet monitor that remains fastened on the child’s hand to transmit the health condition to the monitor. This monitor allows the parents to check their kid’s health without even leaving her bed and can be set to trigger an alarm when the blood sugar level of the child crosses a particular height. Moreover, parents can easily review their child’s nightly activities during the middle of the night at their bedside convenient. If an emergency situation takes place, they can rush to their child’s room with the monitor to perform the aid that has to be taken based on the information displayed on the monitor.

Designer : Megan Langdon and Jordan Diatlo

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